Modular Bioconjugates to Study Herceptin Resistance: A Structural and Functional Approach
Technical Report,15 Sep 2015,14 Sep 2016
University of California, Berkeley Berkeley United States
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The focus of the studies described herein was to apply the developed antibody-capsid conjugates to both the examination of ultra structural features relevant to invadopodia formation as well as mass cytometry probes for the analysis of signaling dynamics in Herceptin resistance development. In working to achieve these goals, a number of challenges were encountered, and the experimental details and assessments are described in the attached report.