Novel Measures of Volume Status and Cardiac Function in Traumatic Shock
Technical Report,01 Jul 2013,31 Jul 2014
USAFSAM/FHE Wright-Patterson AFB United States
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The purpose of this study was 1 to identify better markers of volume status and the adequacy of resuscitation in patients with traumatic shock and 2 to determine the incidence, time course, and clinical relevance of trauma-associated cardiac dysfunction. To achieve these aims, we evaluated a panel of cardiac biomarkers of cardiac function and the focused rapid echocardiographic evaluation serially over time in a civilian model of military trauma. Upon closure of the study, only six patients were enrolled, so no association between biomarkers and outcome could be determined. However, the study found that the majority of severely injured trauma patients have cardiac dysfunction during the initial 24 hours and periodically over 10 days. Furthermore, echo proved to be a safe method to assess volume status and cardiac function. These pilot data suggest that further study of biomarkers and echocardiography in trauma patients is warranted.