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Molecular Signatures of Chronic Pain Subtypes

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Technical Report,13 Dec 2010,12 Dec 2014

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Duke University Durham United States

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This project was a biomarker discovery and novel analgesic pathway discovery program focusing on the causes of persistent pain after traumatic amputation in the combat setting. During this project we have 1 maintained the necessary regulatory approval at WRNMMC and Duke University. We have 1 obtained and maintained documents for approval by MRMC 2 completed patient enrollment at 124 patients 3 maintained our interactive, secure web based data collection system 4 populated our biorepository at Duke with bioresource collected from 124 patients enrolled at WRNMMC 5 conducted further on-site visits and investigator meetings at WRNMMC 6 Received and analysed all data from whole exome sequencing, gene expression, DNA methylation, miRNA, proteomic and metabolomic analysis 7 and begun follow up work on these putative pain biomarkers. We have published three papers, have submitted another and have two more in process. We have achieved four major goals 1 Defined the clinical nature and incidence of chronic pain subtypes in traumatic military amputees 2 Demonstrated the utility of a diagnostic post-amputation pain adjudication algorithm 3 Found that regional anesthesia catheter placement is associated with reduced chronic neuropathic pain in amputees 4 4. Discovered two novel nociceptive pathways that may serve both as biomarkers of pain and novel analgesic targets and we have received follow-up funding to further study these pathways.

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