Accession Number:

AD1021582

Title:

Controlling Mitochondrial Dynamics to Mitigate Noise-Induced Hearing Loss

Descriptive Note:

Technical Report,15 Sep 2015,14 Sep 2016

Corporate Author:

Oregon Health and Science University Portland United States

Personal Author(s):

Report Date:

2016-10-01

Pagination or Media Count:

14.0

Abstract:

In this study, we are examining the efficacy of a potential early intervention therapeutic for noise induced hearing loss NIHL.The generation of reactive oxygen species is one of the underlying mechanisms of noise-induced damage to tissues in the inner ear that leads to noise-induced hearing loss NIHL. The goal is to define an effective post-exposure, non-invasive intervention strategy to mitigate a primary cause of loud-sound induced hearing loss mitochondrial dysfunction and overproduction of reactive oxygen species. Utilizing a localized application procedure to the outer ear canal of a small molecule mitochondrial fission inhibitor, mitochondrial division inhibitor-1, the results so far have demonstrated that inhibition of the mitochondrial fission process significantly attenuates NIHL and reduces damage to the tissues of the inner ear.

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE