A Tense Situation: Forcing Tumour Progression
Journal Article - Embargoed Full-Text
CALIFORNIA UNIV SAN FRANCISCO SAN FRANCISCO United States
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Cells within tissues are continuously exposed to physical forces including hydrostatic pressure, shear stress, and compression and tension forces. Cells dynamically adapt to force by modifying their behaviour and remodelling their microenvironment. They also sense these forces through mechanoreceptors and respond by exerting reciprocal actomyosin- and cytoskeletal-dependent cell generated force by a process termed mechanoreciprocity. Loss of mechanoreciprocity has been shown to promote the progression of disease, including cancer. Moreover, the mechanical properties of a tissue contribute to disease progression, compromise treatment and might also alter cancer risk. Thus, the changing force that cells experience needs to be considered when trying to understand the complex nature of tumorigenesis.
- Anatomy and Physiology
- Medicine and Medical Research