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Do Prostate Cancer Exosomes Generate a Field Effect Leading to Tumor Multifocality

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Technical Report,25 Mar 2015,24 Mar 2016

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Chapman University Orange United States

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Prostate field effect or field cancerization denotes the presence of molecular aberrations featured in structurally intact cells of histologically normal tissues adjacent to adenocarcinomas, in many cases as distant as centimeters from the tumor margin. The presence of a field effect is causatively associated with the occurrence of tumor multifocality in the prostate, but a notable gap of knowledge is the lack of understanding of how multifocal fields of molecular aberrations in histologically normal tissues adjacent to tumors form. We propose a novel line of investigation that will implicate exosomes, extracellular vesicles secreted by prostate epithelial cells, in the formation of field effect and tumor multifocality. The Specific Aims are i to test the effect of prostate cancer exosomes on non-cancerous cells and ii to determine the association between markers of field effect and markers of exosomes in tissues adjacent to adenocarcinomas. Accomplishments so far include i the isolation and partial characterization of exosomes from prostate cells, ii the determination of the effect of prostate cancer cell exosomes on markers of field effect in normal cells, iii the completion of a manuscript, and iv building strategically meaningful alliances.

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