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Investigating the Regulation and Potential Role of Nonhypoxic Hypoxia Inducible Factor 1 (HIF 1) in Aromatase Inhibitor Resistant Breast Cancer

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Technical Report,15 Sep 2011,14 Sep 2015

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University of Maryland, Baltimore Baltimore United States

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This research aims to understand the factors and molecular mechanisms involved in drug-resistant breast cancer, specifically aromatase inhibitor resistant breast cancer. Although aromatase inhibitors AIs i.e., letrozole have been shown to be highly effective in treating estrogen receptor positive ER breast cancer, a significant percentage of patients either do not respond to AIs or become resistant to them. Previous studies suggest that resistance to AIs involves a switch from dependence on ER signaling to dependence on growth factor-mediated pathways, such as human epidermal growth factor receptor-2 HER2. The mechanism by which HER2 is involved in AI resistance remains mostly unclear. It is, therefore, important to elucidate theHER2-mediated pathway that contributes to AI resistance, and to identify other relevant factors involved that can be used as biomarkers of AI resistance or targets for therapy.

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