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HGF/c-MET Pathway in AIDS-Related Lymphoma

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Technical Report,15 Aug 2015,14 Aug 2016

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Louisiana State University System New Orleans United States

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In the first year of funding period, we have almost completed Specific Aim1 subtasks listed in the SOW forms. We also have obtained some promising data for Specific Aim3 subtasks. In summary, we found targeting HGFc-MET pathway induced KSHV PEL cell apoptosis through cell cycle arrest and DNA damage. The Illumina microarray data indicated that there are much more host factors potentially controlled by the HGFc-MET pathway within PEL cells than we previously expected. We also found that selective c-METinhibitor can effectively prevent PEL expansion in the xenograft model, although the underlying mechanisms still being further investigated. During this funding period, we have totally published 8 peer-reviewed articles about the molecular mechanisms of KSHVviral oncogenesis, and developing novel therapeutic strategy against these malignancies, including one in BLOOD journal. In all these publications, I serve as the corresponding or co-corresponding author. We also had oral presentation andor poster display on several national or international meetings. With the support by this DOD award, I recently got a Leukemia Research Foundation pilot funding about the sphing olipid metabolism in AIDS-related lymphomas.

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