Crosstalk between mTORC1 and cAMP Signaling
Technical Report,01 Jul 2013,30 Jun 2016
CALIFORNIA UNIV SAN DIEGO LA JOLLA LA JOLLA United States
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Mutation in TSC1 and TSC2 genes are responsible for tuberous sclerosis complex TSC. The major function of TSC12 is to inhibit mTORC1, thus, uncontrolled mTORC1 activation is the key for TSC. This project studies the molecular mechanisms of negative regulation of mTORC1. We have shown that mTORC1 is potently inhibited by hormones that stimulating cAMP, which acts through protein kinase A PKA to inhibit mTORC1. We observed the mTORC1 is inhibited by osmotic stress and possible role of the NLK kinase in mTORC1. We also discovered that different amino acids stimulate mTORC1 by different mechanisms.