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The Association Between Molecular Markers in Colorectal Sessile Serrated Polyps and Colorectal Cancer Risk

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Technical Report,01 Aug 2015,31 Jul 2016

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Kaiser Foundation Research Institute Portland United States

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The objective of this study is to identify histologic characteristics and molecular markers associated with an increased risk of colorectal cancer in patients with sessile serrated colorectal polyps SSPs. The projects specific aims are as follows 1 Estimate the risk of colorectal cancer or advanced polyps in patients who have SSPs with cytological dysplasia compared to patients with SSPs that lack cytological dysplasia and 2 Evaluate if the risk of incident colorectal cancer or advanced polyps varies according to methylation markers in SSPs. The following progress was made during year 1 Human Subjects approval was obtained from all institutions, SSPs with subsequent colorectal neoplasia and interval cancers were identified, the pathology review form and protocol were finalized, assays for 6 out of the 11 methylation markers were optimized, tissue blocks and clinical H and E slides were pulled for standard pathology review. Also, Dr. Burnett-Hartman participated in regular career development opportunities, including attending clinical research seminars, presenting at national and local research meetings, and connecting with new clinical partners at Kaiser Permanente Colorado. Dr. Burnett-Hartman also maintained regular meetings with mentors and collaborators at the Fred Hutchinson Cancer Research Center, the University of Washington, and Kaisers Institute for Health Research.

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