Accession Number:

AD1018688

Title:

Nanosizing a Metal-Organic Framework Enzyme Carrier for Accelerating Nerve Agent Hydrolysis

Descriptive Note:

Journal Article

Corporate Author:

NORTHWESTERN UNIV EVANSTON IL EVANSTON United States

Report Date:

2016-10-05

Pagination or Media Count:

9.0

Abstract:

We report the synthesis and characterization of a water-stable zirconium metal-organic frameworkMOF, NU-1003, featuring the largest mesoporous aperture known for a zirconium MOF. This material has been used to immobilize the nerve agent hydrolyzing enzyme, organophosphorus acid anhydrolase OPAA. The catalytic efficiency of immobilized OPAA in nanosized NU-1003 is significantly increased compared to that of OPAA immobilized in microsized NU-1003 and even exceeds that of the free OPAA enzyme. This paper highlights a method for rapid and highly efficient hydrolysis of nerve agents using nanosized enzyme carriers.

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE