In the twenty-first century, globalization has linked transnational crime, illicit trafficking, and terrorists. These groups were once distinct in function and makeup, but have now become increasingly similar and connected by decentralized networks and financed by an ever-expanding global illicit economy. Collaboratively these illicit networks pose ever-increasing threats to the national security of countries across the globe. Efforts to counter the threats posed by the broad scope of illicit trafficking is being collaboratively developed by governments across the globe. This paper examined a strategic focused network approach at disrupting illicit trafficking networks and defined the U.S. Department of Defenses role within this strategy.