Accession Number:

AD1018331

Title:

Immunomodulation to Optimize Vascularized Composite Allograft Integration in Limb Loss Therapy

Descriptive Note:

Technical Report,30 Sep 2013,29 Sep 2014

Corporate Author:

Emory University Atlanta United States

Personal Author(s):

• Cendales,Linda C.

Report Date:

2014-10-01

Pagination or Media Count:

5.0

Abstract:

Recent improvements in body armor have reduced the rate of combat death but increased the rate of extremity injury, burnand limb loss in surviving casualties. As such, methods to replace injured limbs are increasingly required to support combatservice personnel. Vascularized composite alltransplantation VCA has recently emerged as a promising strategy for therepair or replacement of amputated limbs, and novel methods for immune management to prevent the rejection of transplantedtissues are now available that may greatly reduce the risks associated with limb transplantation.

Descriptors:

• Surgical transplantation
• transplants
• immunomodulation
• rejection
• intervention
• weapons effects

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE