This paper provides an argument for the U.S. Air Force to invest in a robust space-based Intelligence, Surveillance, and Reconnaissance ISR architecture to support Global Strike in 2035. The detailed investigation provides recommends on future technologies the Air Force can pursue, which will provide relevant space-based ISR capabilities in a congested, contested, and competitive space environment. As these technologies progress and enable continuous space-based ISR collection in the congested, contested, and competitive space environment of 2035 U.S. decision makers will be able to strike globally putting any adversary target at risk. Space-based ISR, along with airborne ISR and cyber, will be able to provide global, ever-present ISR. By 2035 this multi-sensor, multi-domain approach to ISR collection can enable U.S. leadership to consistently operate within an adversarys decision making and action cycle, thus helping enable Global Strike.