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Acquisition of a Laser Scanning Confocal Microscope to Examine CNS Activity of Antidotal Oximes and to Enhance Undergraduate Research Training Across the Sciences

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Technical Report,01 Feb 2015,31 Jan 2016

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Whittier College Whittier United States

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The project utilized funding to acquire a confocal laser scanning microscope Olympus FV1200 to support research examining the ability of antidotal oximes to rescue organophosphate OP-induced CNS toxicity and training across the sciences and social sciences at Whittier College. In particular the acquisition of the FV 1200 allows the PI, Dr. Erica Fradinger, to extend her research of blood-brain-barrier BBB penetrant oxime antidotes to investigate their effects on both OP-induced PNS and CNS toxicity. Additionally, this instrument will support interdisciplinary research activities in the Center for Science, Health, and Policy, support pedagogical advances, and expose students to cutting edge technologies. Users come from the biology, chemistry, physics, and psychology departments. The requested FV 1200 expands the research capacity of four faculty, enhance eight courses in the biology, chemistry and psychology departments, and expand the capstone research projects of students across the sciences. While the research and teaching interests of the participants are diverse, all are able to use the equipment to detect, quantify, or visually localize gene expression products to study protein function at the cellular and sub-cellular levels.

Subject Categories:

  • Test Facilities, Equipment and Methods

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