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High Spatiotemporal Resolution Prostate MRI

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Technical Report,15 Aug 2015,14 Aug 2016

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Mayo Clinic Rochester United States

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Prostate cancer PCa is the second leading cause of cancer death in men. However, when detected and treated promptly the five-year relative survival rate approaches 100 . The overall purpose of this project is to develop improved means using MRI for detecting prostate cancer with the potential for differentiating disease aggressiveness. The hypothesis is that dynamic whole-volume contrast-enhanced perfusion imaging of the prostate gland can be performed with 1 mm isotropic spatial resolution and 2 sec frame times, providing an order of magnitude improvement over current techniques. The specific aims are i to develop an MRI acquisition technique for time-resolved 3D MRI of the prostate, ii to develop a fundamentally new coil element family having variable sensitivity along the superior-to inferior direction, iii to incorporate partial Fourier and acceleration methods into high speed reconstruction to provide high quality 3D images in real time at frame times of 2 sec or less.

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