Development of Silicon-Coated Superparamagnetic Iron Oxide Nanoparticles for Targeted Molecular Imaging and Hyperthermic Therapy of Prostate Cancer
Technical Report,15 Jul 2014,14 Apr 2016
University of Texas MD Anderson Cancer Center Houston United States
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The main goal of the research project is to develop and test a novel class of dual-threat theranostic nanoparticles for targeted imaging and hyperthermic therapy of prostate cancer. These particles consist of both silicon for hyperpolarized magnetic resonance imaging, MRI and superparamagnetic iron oxide for hyperthermic therapy. Preliminary results show that simple mixtures between the two particles still allow for hyperpolarized MRI to take place, albeit with a slightly broadened 29Si NMR lineshape. Six generations of particles have been completed and physically characterized tunneling electron microscopy, dispersive x-ray spectroscopy, electron spin resonance spectroscopy to show a viable coupling between the silicon 300 nm and iron oxide 5 nm, with the iron oxide attached to the surface of the silicon. The hybrid particles can be hyperpolarized for enhanced MR signals using Dynamic Nuclear Polarization. A small-scale hyperthermia device that induces therapeutic heating in the nanoparticles has been set up and used to acquire preliminary results.