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Microtubule Abnormalities Underlying Gulf War Illness in Neurons from Human-Induced Pluripotent Cells

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Technical Report,01 Sep 2015,31 Aug 2016

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Drexel University Philadelphia United States

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The study plan is to develop immortalized cultures of cells from the blood of veterans who are suffering from Gulf War Illness GWI. A simple blood sample is taken from the soldier, and then transduced, using reliable established methods, to make the cells pluripotent. The pluripotent cells lines can then be treated with growth factors to differentiate them into a number of different cell types including neurons. The investigators will develop these cell lines from veterans of the Gulf War who got sick and also from veterans who did not get sick, so the two can be compared. Other scientists studying GWI will be able to use the cell lines for their own studies, which will maximize the effort of the biomedical community to rush medicines and treatment regimens to the veterans who are suffering. For the two-year proposed study, the first year has been devoted to establishing the cell lines, as well as early phases attesting microtubule-based therapies for restoring cellular functions to normal in neurons derived from human pluripotent cells exposed to Gulf War toxins.

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