Accession Number:

AD1017305

Title:

The Effects of Signal Erosion and Core Genome Reduction on the Identification of Diagnostic Markers

Descriptive Note:

Journal Article

Corporate Author:

USAMRIID Frederick United States

Report Date:

2016-09-20

Pagination or Media Count:

26.0

Abstract:

Whole genome sequence WGS data are commonly used to design diagnostics for the identification of bacterial pathogens. To do this effectively, genomics databases must be comprehensive to identify the strict core genome that is specific to the target pathogen. As additional genomes are analyzed, the core genome size is reduced and there is erosion of the target-specific regions due to commonality with related species, potentially resulting in the identification of false positives andor false negatives.

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE