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New Heart Failure Treatment Capability for Remote Environments

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Technical Report,14 Jul 2008,19 May 2012

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Lifebridge Technologies, LLC Dayton United States

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The FINAL annual report summarizes the salient background information and the successful completion of the proposed project with emphasis on accomplishments from 5202012 to 5192013. The purpose of this project was to develop a device for rapid, effective, circulatory support for remote areas. Direct mechanical ventricular actuation DMVA is a non-blood contacting method that can re-establish normal hemodynamics in the fibrillating non-beating and severely failing heart within minutes. This projects objective was to develop a portable, compact, user-friendly DMVA drive system for simplified operation. Proven, pre-existing DMVA drives were used for verifying the new drive met functional requirements. Project objectives were to develop a manual powered hand pump HP, define optimal HP operation, design a motorized drive to power the prototype pump, and then use these inputs to construct the automated, prototype drive. In-vivo testing utilized a dedicated data acquisition system integrated with inputs selected to best interrogate the drive systems functionality and related physiologic effects. Thereby, the HP integrated with a prototype linear drive was been evaluated and reduced to a compact, automated drive AD. The final prototype DMVA drive system was successfully constructed and tested. In-vitro bench testing on a custom mock circulatory loop MCL allowed final modifications to be made prior to verifying the systems functionality with in-vivo animal testing. The AD incorporates a removable HP which enables temporary acute support in the event of power failure. Final in-vitro and in-vivo testing verified the new system achieved functionality equivalent to pre-existing drive systems while providing a portable, AD useful for remote areas.

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