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Umbilical Cord Blood Use for Admission Blood Tests of VLBW (Very Low Birth Weight) Preterm Neonates: A Multi-center Randomized Clinical Trial

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Technical Report,01 Sep 2014,30 Apr 2016

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San Antonio Military Medical Center Fort Sam Houston United States

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Very low birth weight premature neonates undergo phlebotomy procedures on admission to the neonatal intensive care unit that require 10 of their total blood volume. Increasing their likelihood of anemia requiring packed red blood cell transfusion. A strategy to decrease the risk of anemia includes use of umbilical cord blood for admission lab tests. Our objective is to compare the use of umbilical cord vs. infant blood as a strategy to decrease the risk of anemia requiring PRBC transfusion in VLBW infants. Study was designed as a multicenter, prospective, randomized control trial. Participants are infants less than 30 weeks or birth weight less than 1200 grams. Participants randomized to the experimental arm have admission labs drawn from umbilical cord blood. Labs from the control arm are drawn from the infant. The primary outcomes are absolute hemoglobin concentration and percent change in HgB concentration from baseline to 24 hours of life. Interim analysis of 44 patients was performed. The percent change in HgB concentration from baseline to 24 hours of life in the control arm was -3.54 compared with a 7.46 increased HgB concentration in the experimental arm p 0.018. There was also a trend toward higher HgB concentration at 24 hours in the experimental arm.

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  • Medicine and Medical Research

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