Prospective Evaluation of Intraprostatic Inflammation and Focal Atrophy as a Predictor of Risk of High-Grade Prostate Cancer and Recurrence after Prostatectomy
Technical Report,01 Jul 2012,30 Jun 2016
Johns Hopkins University Baltimore United States
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We evaluated, in 2 nested case-control studies, intraprostatic inflammation and focal atrophy as tissue markers for risk of future diagnosis of prostate cancer and for prognosis. For incidence, we found in the placebo arm that 76 of cases and 69 of controls had 1 biopsy core of 3 assessed with inflammation, most of which was chronic. The OR of lower-grade prostate cancer tended to increase with number of biopsy cores with inflammationcompared with 0 cores with inflammation, some cores OR1.96, all cores OR2.94, P-trend0.1. In the finasteride arm, prevalence of inflammation did not differ between cases 76 and controls 75 . For focal atrophy, we observed a possible positive association in the placebo arm, but an inverse association in the finasteride arm we could not rule out treatment effect on the appearance of atrophy in the latter. For prognosis, the OR of recurrence comparing top and bottom quartiles of minimum mast cell density was 0.58 95 CI 0.40-0.86 P trend0.004 taking into account matching factors age, race, Gleason sum, and pathologic stage. We conclude that intraprostatic inflammation pre-dating prostate cancer diagnosis and recurrence may influence risk and prognosis.