Accession Number:

AD1017033

Title:

Coexpression of the Follicle Stimulating Hormone Receptor and Stem Cell Markers: A Novel Approach to Target Ovarian Cancer Stem Cells

Descriptive Note:

Technical Report,01 Sep 2011,31 Dec 2015

Corporate Author:

Duke University Durham United States

Personal Author(s):

Report Date:

2016-03-01

Pagination or Media Count:

20.0

Abstract:

Purpose The purpose of this project was to determine whether the Follicle-stimulating Hormone Receptor FSHR is coexpressedwith a sufficient number of ovarian cancer stem cell markers to consider it as a new experimental target for novelnanotechnology approaches capable of destroying ovarian cancer stemprogenitor cells OCSCs.Scope We examined individual cells obtained from ovarian cancer patients to determine whether they expressed recognizedovarian cancer stem cell markers and the FSHR on the surface membrane of the same cell. Cells co-expressing the markersand the FSHR plus appropriate controls were then tested in mice to determine whether any tumors formed also co-expressedthe same markers.

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE