Accession Number:

AD1017031

Title:

Use of Topical PC-NSAIDs to Treat Burn Injury and Pain

Descriptive Note:

Technical Report,05 Jul 2015,04 Jul 2016

Corporate Author:

The University of Texas Health Science Center Houston United States

Personal Author(s):

Report Date:

2016-08-01

Pagination or Media Count:

15.0

Abstract:

Studies in year two have shown that the rat dorsal skin and hind limb burn injury models are appropriate for testing the analgesic and healing rate efficacy of test drugs. These models were used to test Ibuprofen Ibu, Ibu-PC, Indomethacin Indo, and Indo-PC. The experimental drug Indo-PC showed a tendency for analgesic efficacy over Indo alone or the Ibu drugs, notably when administered parenterally. These studies support a rationale for continued development of parenteral Indo-PC for treatment of 2nd degree burn wounds.

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE