Accession Number:

AD1016788

Title:

Blood Transcriptomics and Metabolomics for Personalized Medicine

Descriptive Note:

Journal Article

Corporate Author:

Emory University School of Medicine Atlanta United States

Personal Author(s):

• Li,Shuzhao
• Todor,Andrei
• Luo,Ruiyan

Report Date:

2015-10-31

Pagination or Media Count:

7.0

Abstract:

Molecular analysis of blood samples is pivotal to clinical diagnosis and has been intensively investigated since the rise of systems biology. Recent developments have opened new opportunities to utilize transcriptomics and metabolomics for personalized and precision medicine. Efforts from human immunology have infused into this area exquisite characterizations of subpopulations of blood cells. It is now possible to infer from blood transcriptomics, with fine accuracy, the contribution of immune activation and of cell subpopulations. In parallel, high-resolution mass spectrometry has brought revolutionary analytical capability, detecting N10,000 metabolites, together with environmental exposure, dietary intake, microbial activity, and pharmaceutical drugs. Thus, the re-examination of blood chemicals by metabolomics is in order. Transcriptomics and metabolomics can be integrated to provide a more comprehensive understanding of the human biological states. We will review these new data and methods and discuss how they can contribute to personalized medicine.

Descriptors:

• TRANSCRIPTION FACTORS
• Metabolomics
• gene expression
• blood cells
• Molecular biology
• Immunology
• mass spectrometry
• biological markers
• data acquistion
• breast cancer
• biotechnology
• Blood chemistry
• genomics

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE