Genetic and Diagnostic Biomarker Development in ASD Toddlers Using Resting State Functional MRI
Technical Report,01 Sep 2014,31 Aug 2015
The University Of Texas Health Science Center At San Antonio San Antonio United States
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The primary objective of this project is to develop fMRI-based characterizations of functional connectivity networks during natural sleep as a neurologic biomarker for ASD that is suitable for diagnostic use in young children ages 1-4. Existing neuroimaging and neuro behavioral resources developed by the principal investigators are being mined for ASD relevant biomarkers. Structural and constrained functional meta-analyses of previously published, peer-reviewed neuroimaging studies in ASD have been conducted to inform regions of-interest for further hierarchical network modeling. We have thus identified 1consistent regions of brain overgrowth atrophy and 2 consistent functional activation differences with social behaviors between ASD and typically developing TD individuals. These regions-of-interest will be extended through additional functional meta-analyses, network models will be created, and these models will be applied to primary ASD data.