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Genetic and Diagnostic Biomarker Development in ASD Toddlers Using Resting State Functional MRI

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Technical Report,01 Sep 2014,31 Aug 2015

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The University Of Texas Health Science Center At San Antonio San Antonio United States

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The primary objective of this project is to develop fMRI-based characterizations of functional connectivity networks during natural sleep as a neurologic biomarker for ASD that is suitable for diagnostic use in young children ages 1-4. Existing neuroimaging and neuro behavioral resources developed by the principal investigators are being mined for ASD relevant biomarkers. Structural and constrained functional meta-analyses of previously published, peer-reviewed neuroimaging studies in ASD have been conducted to inform regions of-interest for further hierarchical network modeling. We have thus identified 1consistent regions of brain overgrowth atrophy and 2 consistent functional activation differences with social behaviors between ASD and typically developing TD individuals. These regions-of-interest will be extended through additional functional meta-analyses, network models will be created, and these models will be applied to primary ASD data.

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