Accession Number:

AD1016784

Title:

Maternal Brain-Reactive Antibodies and Autism Spectrum Disorder

Descriptive Note:

Technical Report,30 Sep 2014,29 Sep 2016

Corporate Author:

Feinstein Institute for Medical Research Manhasset

Personal Author(s):

• Diamond,Betty

Report Date:

2015-10-01

Pagination or Media Count:

67.0

Abstract:

We have determined that one monoclonal antibody cloned from the memory B cell population of the mother of a child with ASD binds Caspr2. This antibody disrupts fetal brain development and leads to an ASD-like phenotype in the offspring. Forty percent of women with brain-reactive serology and a child with ASD exhibit antibodies to Caspr2 thus this antibody may contribute to approximately 5 of cases of ASD.

Descriptors:

• brain
• gene expression
• proteins
• biomedical research
• antibodies
• BEHAVIOR
• BRAIN FUNCTION IMPAIRMENT
• MENTAL DISORDERS

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE