Maternal Brain-Reactive Antibodies and Autism Spectrum Disorder
Technical Report,30 Sep 2014,29 Sep 2016
Feinstein Institute for Medical Research Manhasset
Pagination or Media Count:
We have determined that one monoclonal antibody cloned from the memory B cell population of the mother of a child with ASD binds Caspr2. This antibody disrupts fetal brain development and leads to an ASD-like phenotype in the offspring. Forty percent of women with brain-reactive serology and a child with ASD exhibit antibodies to Caspr2 thus this antibody may contribute to approximately 5 of cases of ASD.