Rescue of TET2 Haploinsufficiency in Myelodysplastic Syndrome Patients Using Turbo Cosubstrate
Technical Report,20 Jun 2015,19 Jun 2016
University of Missouri, Kansas City Kansas City United States
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During this period we made a library of putative 2-oxoglutarate 2OG analogs. This library is used to enhance the activity of TET2 enzymes from MDS patient. Our results shows that the activity of TET2 can be dramatically modified using 2OG analogs.