Accession Number:

AD1016765

Title:

Rescue of TET2 Haploinsufficiency in Myelodysplastic Syndrome Patients Using Turbo Cosubstrate

Descriptive Note:

Technical Report,20 Jun 2015,19 Jun 2016

Corporate Author:

University of Missouri, Kansas City Kansas City United States

Personal Author(s):

Report Date:

2016-07-01

Pagination or Media Count:

20.0

Abstract:

During this period we made a library of putative 2-oxoglutarate 2OG analogs. This library is used to enhance the activity of TET2 enzymes from MDS patient. Our results shows that the activity of TET2 can be dramatically modified using 2OG analogs.

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE