Diagnostic and Treatment Innovations for Mass Casualties
Technical Report,01 Apr 2008,31 Mar 2011
University of South Florida Tampa United States
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It was proposed to define the very early molecular response to soft tissue and vascular injury. That information was applied to develop innovative diagnostic technologies and targeted pharmacologic and genetic therapies. The research strategy consisted of two main goals 1 quantify the very early inflammatory response to cardiovascularsoft tissue trauma to define an injury severity predictive panel of biomarkers to be incorporated into a sensor 2 design and test novel therapeutic approaches using pharmacologic and gene delivery systems to accelerate andor stabilize reparative processes leading to greater injury survivability.