The desire to innovate and transform defense acquisition is ill-informed regarding the true meaning of innovation and transformation. The Department of Defense DOD would be best served by radical modifications driven by a capitalist market approach to freedom and accountability. A fruitful shift in DOD weapons acquisitions would embrace concepts from the biotech industrysuch as being science-based and open to innovative applications of technologyand implement required changes in doctrine and organization. While the need for reform is obvious, the will to reform is less evident. However, examples and lessons from private business sectors would serve DOD interests well.