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Development of in Vivo Biomarkers for Progressive Tau Pathology after Traumatic Brain Injury

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Technical Report,15 Jan 2015,14 Jan 2016

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Washington University St Louis United States

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Hypothesis Aggregated forms of hyperphosphorylated tau protein formed acutely in the setting of traumatic brain injury can seed further aggregation of intracellular tau in nearby cells, leading to delayed propagation of tau pathology and neurodegeneration. Objective To develop standardized, high-throughput blood and cerebrospinal fluid assays for aggregated forms of tau responsible for propagation of tau pathology after traumatic brain injury. Progress to date To date, none of the attempts to model progressive tau pathology after repetitive concussive TBI in mice has been optimal. Ongoing efforts include development rotational acceleration concussive injury which can be repeated 20 times in the same mice, and subconcussive injuries. Continued progress towards increasing the sensitivity of cell-based assays for tau aggregation activity has been made, as well as antibody-based tau detection methods for blood samples.

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