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Brain MR Spectroscopy Biomarkers in a Clinical Trial of PTS Patients With Comorbid AUD

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Technical Report,01 May 2015,30 Apr 2016

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Northern California Institute for Research and Education (NCIRE) San Francisco United States

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This human neuroimaging application builds on the successful high-field neuroimaging program under the umbrella of the longstanding collaboration between the DoD and the Northern California Institute for Research and Education NCIRE, carried out jointly by investigators of the Center for Imaging of Neurodegenerative Diseases CIND and treatment staff from the VA Mental Health Services. Our overall goal is to determine if topiramate facilitates functionally significant adaptive modulation of -aminobutyric acid GABA and glutamate levels in the neocortex of 40 alcohol dependent veterans with posttraumatic stress disorderPTSD. We propose to perform longitudinal proton magnetic resonance spectroscopy 1H MRS as an addendum to an ongoing double-blind placebo controlled trial of topiramate in the treatment of alcohol dependence in veterans with PTSD. Longitudinal control studies will be conducted in 10 healthy controls. All studies will be performed on a 3T scanner and half the sample will also be scanned on the new 7T scanner to assess its utility in patient research.

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