Accession Number:

AD1014570

Title:

Pregnancy Specific Glycoprotein 17 Binds to the Extracellular Loop 2 of its Receptor, CD9, and Induces the Secretion of IL-lO, IL-6, PGE2 and TGFbeta1 in Murine Macrophages

Descriptive Note:

Technical Report

Corporate Author:

UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD BETHESDA United States

Personal Author(s):

Report Date:

2004-07-09

Pagination or Media Count:

142.0

Abstract:

Pregnancy specific glycoproteins PSGs are a family of proteins produced by primate and rodent placentas and secreted into the maternal circulation. In humans PSGs are detected in maternal serum from the time of implantation, and their concentration increases when pregnancy progresses, reaching 200-400 microgramml at term. The correlation between low levels of PSGs and poor pregnancy outcomes suggests PSGs play a role in the regulation of maternal immunity to the semi-allogeneic fetus. We have previously reported that human and murine PSGs induce anti inflammatory cytokines in monocytes, and identified CD9 as the cellular receptor form urine PSG17. However, the role of CD9 in cytokine induction mediated by PSG17 as well as the signaling mechanism triggered in macrophages in response to PSG17 remain largely unknown. The present research attempted to shed light on these two areas

Subject Categories:

  • Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE