Identification of Associations Between Genetic Factors and Asthma that are Modified by Obesity
Technical Report,01 Feb 2013,01 Oct 2015
Yale University New Haven
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We performed a genome-wide gene by environment asthma interaction analysis for the outcome of body mass index BMI in the Multi-Ethnic Study of Atherosclerosis MESA N2474 Caucasians, 257 asthmatics and replicated findings in the Framingham Heart Study FHS offspring cohort N1408 Caucasians, 382 asthmatics. The replicable tagging single nucleotide polymorphism SNP rs2107212 was further examined in stratified analyses. Seven SNPs clustered in 17q21.2 were identified to be associated with higher BMI among asthmatics interaction p 5 10-7 in MESA and p 0.05 in FHS. Nominally associated copy number variations interacting with BMI were associated with asthma among African American women in the Womens Health Initiative study.