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A Mathematical Model of the Human Small Intestine Following Acute Radiation and Burn Exposures

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Technical Report

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Applied Research Associates, Inc. Arlington United States

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Exposure to burn and radiation elicit epithelial cell death in the small intestine, reducing the density of the gut barrier. A reduced epithelial lining can result in suppressed nutrient absorption, bacterial translocation and mortality. This report describes the development of a mathematical model of small intestine epithelial cell kinetics following acute radiation and burn combined injury. This model has been developed from an existing system which simulates dynamic response of the small intestine epithelial cells to acute radiation alone. The model has been modified for improved radiation response, and an addition to the model allows for thermal injury response. A murine model has been developed to aid in the development of the human model due to data limitations. This model provides valuable time-dependent estimations of small intestinal damage, which can be useful in various scenarios of casualty estimation.

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