Cognitive Function and Emotional Status of Middle-aged Chinese Hypertensive Patients Without Detectable White Matter Brain Lesions or Lacunar Infarctions
Uniformed Services University Of The Health Sciences Bethesda United States
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Introduction Essential hypertension EH is associated with cognitive deficits, and higher blood pressure levels have been related to lower levels of cognitive function. Executive functions, speed of processing, memory and attention are especially impacted. Hypertension may affect cognitive function because of pathological physiological changes in the brain e.g., white matter lesions andor lacunar infarctions or behavioralemotional alterations associated with hypertension e.g., stress, anxiety, and depression. Objectives 1 Rule out white matter lesions and lacunar infarctions as necessary causes of cognitive deficits in EH 2 Examine the role of anxiety and depression as a potential mechanism for the relationship between EH and cognitive function and 3 Determine socio-demographic and medical moderators of this relationship in individuals without structural brain changes.