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Early Detection of Amyloid Plaque in Alzheimer's Disease via X-ray Phase CT

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Technical Report,15 May 2012,14 May 2016

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Emory University Atlanta United States

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In this project, we proposed to develop the x-ray phase contrast CT PCCT imaging method for early detection of amyloid plaque in Alzheimers disease, with three Specific Aims 1 Develop and optimize an x-ray PCCT to explore the methodology of direct imaging of AP 2 Evaluate the PCCTs capability of imaging Abeta 1-40Abeta 1-42 peptidesfibrils at the concentrations existing in AD brain 3 Verify the PCCTscapability of direct imaging of AP in AD using postmortem brain specimens. Even though the fabrication of x-ray gratings were much morecomplicated and challenging than initially anticipated, the prototype x-ray PCCT has been built successfully and works in full functionality.We imaged the specimens of AD brain, normally aged brain and pathologically aged brain, with three major findings i the contrast betweengrey matter and white matter in x-ray PCCT image is substantially higher than that in conventional CT image, ii given identical x-ray dose,the PCCT image of brain specimen is of substantially higher signal-to-noise ratio SNR than that of conventional CT image, and iii evenwith substantially improved SNR, the PCCT still cannot convincingly differentiate the AD brain specimen with amyloid plaques from thenormal aged brain specimen without amyloid plaques, probably due to the fact that, limited by the output power of micro-focus x-ray tube, the acquisition of one set of projection by the prototype system takes about 12 hours, which may degrade the prototype systems imaging performance significantly thus opportunity for future research. Under partial support of this grant, five journal papers have been published in Medical Physics, and more than eight papers in leading international conferences.

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