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Evaluation of the Adult Goldfish Brain as a Model for the Study of Progenitor Cells

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Technical Report

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Uniformed Services University Of The Health Sciences Bethesda United States

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Our understanding of the cellular and molecular mechanisms underlying adult neurogenesis in response to diseases of the CNS is incomplete. Decreased neurogenesis in the adult hippocampus in response to stressors is well established in rodent and nonhuman primate models of depression. Recently, increased neurogenesis has been linked to the actions of certain antidepressants, including tranylcypromine TCP in the treatment of depression. The goldfish Carassius auratus has the ability to grow its body and brain throughout its life and is an ideal model for studying adult neurogenesis. The hypothesis was that alterations in adult goldfish proliferation zones can be used to determine antidepressant effects on proliferation. Three specific aims were used to test this hypothesis 1 To produce an atlas of the goldfish brain based on cresyl violet stained sections. 2 To construct an atlas of proliferation zones the goldfish brain. 3 To study the influence of the antidepressant tranylcypromine on progenitor cell proliferation zones in the telencephalon, optic tectum, and cerebellum of adult goldfish.

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