Adolescent Rats Differ by Genetic Strain in Response to Nicotine Withdrawal
Uniformed Services University Of The Health Sciences Bethesda United States
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Gender is a powerful predictor of initiation and maintenance of cigarette smoking in adults, but less is known about smoking in adolescents. Thisresearch examined nicotine withdrawal behaviors in 96 adolescent, male and female, Sprague-Dawley SO and Long-Evans LE rats. Rats received sevendays continuous subcutaneous infusion of saline or nicotine hydrogen tartrate via Alzet osmotic minipumps. Behavioral observations were made before, during,and after saline or nicotine administration. SO male and female rats that received nicotine displayed significantly more withdrawal behaviors one and twodays after cessation of nicotine administration compared with rats that had received saline. LE male rats that received nicotine displayed significantly morewithdrawal behaviors one day but not two days after cessation of nicotine administration compared with males that received saline.