Pregnancy Specific Glycoprotein 23 binds to CD151 and Induces the Secretion of IL-10 and TGF-beta1 in Murine Macrophages
Uniformed Services University Of The Health Sciences Bethesda United States
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Pregnancy-specific glycoproteins are placentally secreted proteins present in the maternal circulation. They are the most abundant fetal protein in late pregnancy and correlate with human pregnancy success. Previously, we identified the tetraspanin CD9 as the receptor for PSG17. This interaction is required for PSG17 mediated anti-inflammatory cytokine production. The present research analyzes the functions and receptor binding of PSG23 in relation to PSG17.