Accession Number:

AD1013996

Title:

The Effect of Traumatic Stress on Multiple Aminergic Systems in the Basolateral Amygdala and Hypothalamus: Specific Impairment of Serotonin 5-HT2a Receptor Signaling and its Pathophysiological Role in an Animal Model of Post Traumatic Stress Disorder

Descriptive Note:

Technical Report

Corporate Author:

Uniformed Services University Of The Health Sciences Bethesda United States

Personal Author(s):

• Jiang,Xiaolong

Report Date:

2007-02-27

Pagination or Media Count:

200.0

Abstract:

The amygdala and hypothalamus are central brain regions participating in stress response. This response also requires participation of multiple aminergic systems, which extensively interconnect with the amygdala and hypothalamus. Thus, dysregulation of aminergic systems, particularly the serotonergic and noradrenergic systems, is closely linked with multiple anxiety and stress disorders. The present study, utilizing a learned helplessness stress model, determined if alterations of aminergic systems in the amygdala and hypothalamus were involved in stress-induced behavioral and physiological abnormalities associated with anxiety and stress disorders.

Descriptors:

• hypothalamus
• brain
• TRAUMATIC STRESS DISORDER
• ANXIETY DISORDERS
• ELECTROPHYSIOLOGICAL PHENOMENA

Subject Categories:

• Medicine and Medical Research
• Psychology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE