Regulation of Brain Glucose Metabolic Patterns by Protein Phosphorlyation and Drug Therapy
Uniformed Services University Of The Health Sciences Bethesda United States
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Glucose metabolism is the main energy-producing pathway of the central nervous system under normal conditions. Thus the regulation of brain glucosemetabolism is essential to maintaining homeostasis. This study aims to determine whether the phosphorylation status of the pyruvate dehydrogenase complex differentiates the metabolic phenotype of astrocytes and neurons in vitro and to determine whether antipsychotic drug administration affects glucose metabolites in vivo. The results of this study demonstrate that the phosphorylation status of the pyruvate dehydrogenase complex underlies the glycolytic phenotype of astrocytes and the oxidative phenotype of neurons in culture. In cultured astrocytes this phenotype can be altered to resemble that of neurons by treatment with the pyruvate dehydrogenase activating compound dichloroacetate.