Accession Number:

AD1013850

Title:

Influence of Herpes Simplex Virus Latency-Associated Transcript (LAT) on the Distribution of Latently Infected Neurons

Descriptive Note:

Technical Report

Corporate Author:

Uniformed Services University Of The Health Sciences Bethesda United States

Personal Author(s):

• Bertke,Andrea S.

Report Date:

2007-03-20

Pagination or Media Count:

196.0

Abstract:

Herpes simplex virus types 1 and 2 HSV-1 and HSV-2 are similar viruses with several notable differences. While both viruses establish latency in sensory ganglia and reactivate to cause recurrent disease, HSV-1 reactivates more efficiently from trigeminal ganglia to cause cold sores or keratitis and HSV-2 reactivates more efficiently from lumbosacral dorsal root ganglia DRG to cause genital herpes. Both viruses are capable of causing central nervous system CNS disease, but HSV-1 CNS infections typically manifest as severe necrotizing encephalitis while HSV-2 is more commonly associated with relatively benign meningitis. Potential mechanisms for type-specific differences between HSV-1 and HSV-2 have not been closely examined, although the latency associated transcript LAT of HSV plays a critical role in the establishment of latency and site-specific reactivation and may have regulatory influence over viral replication and spread

Descriptors:

• HERPES SIMPLEX VIRUS
• AUTONOMIC NERVOUS SYSTEM
• central nervous system
• kINASES
• TRANSCRIPTION GENETICS
• gene expression
• spinal cord
• neurons
• PATHOGENIC MICROORGANISMS
• infectious diseases
• GANGLIA
• stress physiology
• response biology

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE