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Social Support, Heart Failure, and Acute Coronary Syndromes: The Role of Inflammatory Markers

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Technical Report

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Uniformed Services University Of The Health Sciences Bethesda United States

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Heart failure HF is a growing clinical and public health problem associated with high morbidity and mortality. Structural and functional social support are implicated in the development and progression of cardiovascular disease CVD, but not studied as a predictor of incident HF, and the bio-behavioral mechanisms that may underlie this relationship have not been examined. Inflammation, given its role in CVD and HF, may be one promising pathway. Study I used data from the Cardiovascular Health Study CHS to prospectively determine the value of structural vs. functional social support as a predictor of incident HF and the mediatingrole of inflammatory markers Interleukin-6 IL-6 and C-reactive protein CRP. Study II examined the relationship between specific types of structural and functional social support and inflammatory markers IL-6, CRP, and tumor necrosis factoralpha TNF-alpha in a group of patients hospitalized with an acute coronary syndrome.

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