Accession Number:

AD1013654

Title:

Use of Isolated Mitochondria and Pulmonary Artery Endothelial Cell Systems in Studies of Oxygen Utilization and the Effects of Hemoglobin-Based Oxygen Carriers

Descriptive Note:

Technical Report

Corporate Author:

Uniformed Services University Of The Health Sciences Bethesda United States

Personal Author(s):

• Karaian,John E.

Report Date:

2008-07-16

Pagination or Media Count:

76.0

Abstract:

Hemoglobin-based oxygen carriers HBOCs with various oxygen affinities are currently being evaluated for clinical use. We tested whether HBOCs with high vs. low oxygen affinities can affect molecular oxygen on and offloading, using isolated mitochondria and Bovine Pulmonary Artery Endothelial CellsBPAECs as model systems.

Descriptors:

• mitochondria
• blood
• blood transfusions

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE