Accession Number:

AD1013498

Title:

Evaluation of NF-B Signaling in T Cells

Descriptive Note:

Technical Report

Corporate Author:

Uniformed Services University of the Health Sciences Bethesda United States

Personal Author(s):

• Kingeter,Lara M.

Report Date:

2009-01-01

Pagination or Media Count:

71.0

Abstract:

The studies presented in this thesis describe experiments designed to increase our understanding of how T cells transduce activating signals to the transcription factor NF-B, and to better understand the kinetic nature of NF-B signaling. The overarching goals of this thesis are 1 to evaluate T cell receptor mediated activation of the transcription factor NF-B in the absence of key signaling proteins, and 2 to define the mechanisms of signal transduction to NF-B by identifying the point at which signaling becomes digital in nature.

Descriptors:

• cells(biology)
• Transcription(Genetics)
• Receptor sites(Physiology)
• kinetics
• cellular structures
• lymphocytes
• transcription factors
• gene expression
• adaptive immunity

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE