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Biological and Genomic Differences of ERG Oncoprotein-Stratified Prostate Cancers from African and Caucasian Americans
Technical Report,30 Sep 2014,29 Sep 2015
Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. Bethesda United States
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There is striking disparity in prostate cancer incidence and mortality for African American men as compared to Caucasian Americans. The objective of this proposal is to determine associations and racial differences in the distribution of key clinico-pathologic patient features and molecular determinants for both ERG positive and ERG negative prostate cancer. It is anticipated that molecular determinants of aggressive prostate cancer in African American men, including somatic mutations and SNPs associated with prostate cancer risk, may associate with ERG fusion negative prostate cancer.
APPROVED FOR PUBLIC RELEASE