Accession Number:

AD1013482

Title:

Biological and Genomic Differences of ERG Oncoprotein-Stratified Prostate Cancers from African and Caucasian Americans

Descriptive Note:

Technical Report,30 Sep 2014,29 Sep 2015

Corporate Author:

Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. Bethesda United States

Personal Author(s):

• Petrovics,Gyorgy

Report Date:

2015-10-01

Pagination or Media Count:

12.0

Abstract:

There is striking disparity in prostate cancer incidence and mortality for African American men as compared to Caucasian Americans. The objective of this proposal is to determine associations and racial differences in the distribution of key clinico-pathologic patient features and molecular determinants for both ERG positive and ERG negative prostate cancer. It is anticipated that molecular determinants of aggressive prostate cancer in African American men, including somatic mutations and SNPs associated with prostate cancer risk, may associate with ERG fusion negative prostate cancer.

Descriptors:

• prostate cancer
• ethnic groups
• neoplasms
• african americans
• mutations
• caucasians

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE