Accession Number:

AD1013358

Title:

Neurogenin1 Expression and Function in the Developing Mouse Cerebellum

Descriptive Note:

Technical Report

Corporate Author:

Uniformed Services University Of The Health Sciences Bethesda United States

Personal Author(s):

• Lundell,Travis G.

Report Date:

2011-12-14

Pagination or Media Count:

130.0

Abstract:

The basic helix-loop-helix bHLH transcription factors Ptf1a and Math1 are necessary for the specification of gamma-aminobutyric acid GABA-ergic andglutamatergic cell lineages in the cerebellum, respectively. Recent evidence suggests that cascades of bHLH factor activities drive cell type specificity in Ptf1a-positive and Math1-positive lineages. Neurogenin1 Neurog1 is a bHLH transcription factor involved in the development of several nervous system structures including the cerebral cortex, trigeminal sensory neurons, inner-ear sensory neurons, and olfactory sensory neurons. Recently, expression of Neurog1 has been reported to be co-expressed in Ptf1a expressing cells in the ventricular zone VZ of the developing cerebellum, suggesting a role in subtype specification of GABAergic progenitor cells.

Descriptors:

• NEUROTRANSMITTERS
• nerve cells
• CEREBELLUM
• mice
• NERVE FIBERS
• STEM CELLS
• neurobiology
• gene expression
• TRANSCRIPTION GENETICS
• central nervous system
• proteins
• receptor sites (physiology)
• IMMUNOASSAY

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE