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Neurogenin1 Expression and Function in the Developing Mouse Cerebellum
Uniformed Services University Of The Health Sciences Bethesda United States
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The basic helix-loop-helix bHLH transcription factors Ptf1a and Math1 are necessary for the specification of gamma-aminobutyric acid GABA-ergic andglutamatergic cell lineages in the cerebellum, respectively. Recent evidence suggests that cascades of bHLH factor activities drive cell type specificity in Ptf1a-positive and Math1-positive lineages. Neurogenin1 Neurog1 is a bHLH transcription factor involved in the development of several nervous system structures including the cerebral cortex, trigeminal sensory neurons, inner-ear sensory neurons, and olfactory sensory neurons. Recently, expression of Neurog1 has been reported to be co-expressed in Ptf1a expressing cells in the ventricular zone VZ of the developing cerebellum, suggesting a role in subtype specification of GABAergic progenitor cells.
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