Activation of mTor Signaling by Gene Transduction to Induce Axon Regeneration in the Central Nervous System Following Neural Injury (Addendum)
Technical Report,21 Feb 2015,20 Feb 2016
Columbia University Medical Center New York United States
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A long-standing belief about injuries and diseases of the brain and spinal cord has been that once axons are destroyed, they will not re-grow. This belief is now being challenged. As the brain matures, the genetic programs that control axon growth during development are silenced. Recent evidence shows that re-activation of these programs in the adult successfully induces axon growth. We have shown that re-activation of AktmTORC1 signaling, by use of AAV vector transfer, induces regrowth of dopaminergic axons at 3 to 6 weeks after destruction by a neurotoxin. However, this approach cannot be used inhumans because AktmTORC1 signaling is oncogenic. The goal of this proposal is to refine this approach to achieve restorative effects in the absence of adverse effects.