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A Neurobehavioral Phenotype of Blast Traumatic Brain Injury and Psychological Stress in Male and Female Rats
Uniformed Services University Of The Health Sciences Bethesda United States
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Current wars are taking physical and psychological tolls on American service members. Many Warriors return with traumatic brain injuries TBI and mental health problems. Psychological stress that Warriors experience might contribute to the TBI-mental health problem relationship. This experiment examined blast injury and psychological stress in male and female rats. A blast over pressure paradigm BOP was used to model blast exposure. A combination of predator and environmental stressors was used to stress the rats. A measure of neurobehavioral functioning NSS-R and measures of activity were collected. The blast exposure via the BOP model increased NSS-R scores in blasted animals. Psychological stress attenuated negative effects of blast-induced injury on neurobehavioral function in male rats, but potentiated negative neurobehavioral effects of blast-induced injury in female rats. Future research could use the BOP model to investigate mechanisms that underlie these neurobehavioral effects and potential preventive and treatment interventions.
APPROVED FOR PUBLIC RELEASE